![]() ![]() Expect live performances by school and community groups, health screenings, educational workshops, vendors, games, soul food, and more. Benjamin LeathermanĮastlake Park, 1549 East Jefferson StreetThe free Valley of the Sun Juneteenth celebration hosted by the Arizona Informant Foundation will features in-person activities at Eastlake Park Community Center. Showtimes vary each evening and tickets are $22 (plus a two-drink minimum) per set. His summer stand-up tour will start off in the Valley with a three-night stint at CB Live, and he’s not only promising all-new material but is also offering to take selfies afterward with anyone who attends. Conover’s standup comedy is equally brainy, as he jokes about such topics as growing up in a family of geniuses, science, and his own lack of depth perception. The actor, writer, podcaster, and “investigative comedian” has made a career of demystifying difficult concepts or debunking myths, first on his TruTV edutainment show Adam Ruins Everything and then on the Netflix limited series The G Word (which helped explain how the federal government works). If there was a living embodiment of the “well, actually” trope associated with nerddom, Adam Conover would be it. Attendees can also get a photo with a life-sized Buzz Lightyear. Activities will include laser tag sessions, glowing starcraft displays, live entertainment, and movie pass giveaways. Lynn Trimble and Benjamin Leathermanĭesert Ridge Marketplace, 21001 North Tatum BoulevardIn honor of the Disney animated film Lightyear debuting in theaters later this month, The District at Desert Ridge Marketplace will host a free launch party inspired by the film. ![]() He’ll then start posting clues to the various locations on his social media feeds beginning at 9 p.m. As with Hunt’s previous, um, hunts, a treasure trove of zines, sticker and button packs, screen-printed posters, and original art pieces will be hidden in and around the Tempe area. Nxoeed, has been doing for years and will do so again on June 17 in honor of his 50th birthday on June 17. But seeking out art in the streets is just as rewarding - especially when you know a local creative has hidden paintings for people to find. Of course, it’s fine to search for art in traditional venues such as galleries and museums. Various locations in TempeThe thrill of the hunt can rival the satisfaction of a good find. ![]()
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![]() ![]() If religion really is this sexy, then we are believers! The Hits Keep Coming With Frida And Ask The Dusk In Dogma, too, she played a sexy dancer who also happened to be a messenger of God. Rodriguez cast her again in From Dusk Till Dawn which featured her as a dancer in a strip club. There was so much passion between these Spanish-language stars that it got the attention of moviegoers in America who needed to see more.Įven when stopping short of nudity, like the steamy stripteases in From Dusk Till Dawn (1995) and Dogma (1999), Salma is naughty. It is extra spicy and it is sure to please your pepper. This scene is a Skin Classic for a reason. Speaking of close-ups, we get great closeups of her perfectly round pair of jugs. They passionately make love in a variety of positions and a cowboy spur is even run against her smooth, bare skin in close-up shots. Her juicy boobies starred opposite Antonio Banderas in a candlelit sex scene that will make you hot under the collar. This spicy dish served up her chesty chimichangas in this sizzling platter of a movie. Rodriguez loved Salma's fiery passion, so he hired her to star in Desperado (1995). She vented while on a Spanish language talk show that director Robert Rodriguez just so happened to be watching. She felt like American directors were not taking her seriously and that she was consistently being hired to play maids and foreigners. Her pint-sized, hourglass figure first made its appearance on the short-lived TV sitcom The Sinbad Show. It's a great thing that she did! Salma Hayek's First Nude Scene The show was very popular, but she wanted to be a real Hollywood hottie and a global sensation so she left the show and Mexico behind in 1991 to take over Los Angeles. ![]() In fact, it was off to an even better start than the young Salma Hayek had probably anticipated. All of this is to say, that her acting career in Mexico was off to a grand start. She even won some daytime TV show awards. Her role in the series was beloved by Mexican audiences at the time. Her breakthrough role in her native Mexico was in the soap opera Teresa. They practically came knocking at her door after finding out about this heavenly hottie. It truly did not take long for the Mexican Mamacita to get the attention of the local TV and film industry in Mexico. After she got her education, she decided it was time to become a star. ![]() She was actually sent to boarding school in America (specifically New Orleans) when she was a tween and wound up going to university back in Mexico City. She wanted to become an actress after watching Willy Wonka and the Chocolate Factory at a local movie theater when she was a child. Being hot is in her blood, sweat, and sumptuous skin. It is mighty hot in Mexico, which explains South of the Border sexpot Salma Hayek's innate hotness by nature. We are talking about taking a little journey down to the village of Coatzacoalcos in Veracruz, Mexico where Salma Hayek was born. No, not south of her border although we do go there eventually. But where did Salma Hayek come from? Where did it all begin? For those answers, we have to take a trip south of the border. She could stand there in a plastic bag and we would all be fantasizing about doing unspeakable bedroom business to Salma Hayek. Well, she is honestly drop-dead gorgeous in everything that she does. At only 5'2", this short and sweet sexpot has gone nude many times and she has been sexy many more. Those three words probably describe her best of all - not just her voice. This Virgo vixen is best known for her hourglass figure and her seductively deep voice which is filled with confidence, authority, and sensuality. With fourteen nude clips and three full pages of sexy clips that feature Salma Hayek in her underwear and showing massive cleavage, Salma Hayek is a Skin Hall of Famer for sure. Of course, there are! The good news is that there are actually a lot of photos and clips of Salma Hayek in the buff. But everything is getting a green light today boys. You might be wondering: where can I see Salma Hayek's nude photos? Where can we see photos of Salma Hayek nude? Clips of Salma Hayek nude? Is there a Salma Hayek sex tape? Okay, well there isn't. There is simply no denying how effortlessly gorgeous this golden-skinned beauty is. ![]() People have been in steady agreement for decades that Salma is sexy. She is a Mexican actress of Lebanese and Mexican/Spanish descent who has had the world on its knees since she began her acting career in the 1990s. Who has consistently been voted the sexiest woman in the entire world? The answer is the one and only Salma Hayek. ![]() ![]() ![]() No matter what you wear it with, you can always rep your favorites with AE graphic tees for women. Pair them with your fave women’s jeans like Baggy jeans, Mom jeans, and '90s jeans for a look that’s all you, and add women’s tops layers like flannels, cardigans, sweatshirts, and hoodies to stay warm when temps dip. Sport your new graphic tee at your next party or event to let people know exactly what you’re all about. Whether your style is a little more country, rock ‘n roll, city-inspired or team-based, American Eagle vintage graphic tees for women have got you covered with a laid-back style you can take anywhere. Wear them with essential leggings or joggers for an easy-breezy style, or with women’s shorts, jeans, and khaki pants to level up the look. Whatever you’re into, we’ve got you covered with the best designs and fits out there. 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Mens T-Shirts Rainbow T-shirt For Men Summer Colorful Graphic 3D Print Tees La Hip Hop T Shirt 2022 Harajuku Top Watercolor Smoke Tee CAD 7.54 / Piece US 11. Today Only - 30 Off Outkast Photo Collage T-Shirt 16.73 - 19.53 23.90 - 27.90 Today Only - 30 Off Notorious B.I.G. Step up and make your statement with boohoo Canada. Contact Fashion Nova at 2801 East 45th, Vernon, CA 90058 +. Express yourself with cute but edgy graphic tees, including slogan, animal print, and long sleeve edits. You can withdraw your consent at any time by texting STOP to 55525. Consent is not a condition of any purchase. cart reminders) from Fashion Nova CA at the cell number used when signing up. By submitting this form, you agree to receive recurring automated marketing text messages (e.g. 13.60 (60 OFF) 34.00 Not A Lot Going On Graphic T-shirt 13.60 (60 OFF) 34.00 Cowboys Club Graphic Oversized Cropped T-shirt 13.60 (60 OFF) 34.00 Fleetwood Mac Graphic Band T-Shirt 19.60 (60 OFF) 49.00 PLUS SZE Plus Size Aerosmith Graphic Oversized T-Shirt 18.40 (60 OFF) 46. ![]() īy signing up for email, you agree to Fashion Nova's Terms of Service and Privacy Policy. Contact Fashion Nova at 2801 East 46th, Vernon, CA 90058 +. You can withdraw your consent at any time by texting STOP. By signing up for email, you agree to Fashion Nova's Terms of Service and Privacy Policy.īy submitting this form, you agree to receive recurring automated marketing text messages (e.g. Graphic Tees Boutique Take The Trip Neon Coral Graphic Tee Take The Trip Neon Coral Graphic Tee GLITZY Aqua Sky Graphic Tee GLITZY Aqua Sky Graphic Tee. ![]() ![]() ![]() If you want to tweak effects to your liking, go into the resourcepack \assets\minecraft\shaders\program" and edit sildurs_shaders.fsh with something like notepadd .Įxample: //#define Bloom means Bloom is disabled, removing the two slashes - #Bloom enables it. Go to video settings - options and set graphics to fabulous. Launch Minecraft and select the resourcepack from the list.ģ. Download the resourcepack and move it into your resourcepack folder.Ģ. Select my shaderpack from the list ingame and enjoy your new visuals!įabulous shaders using mojangs inbuild shaders support, supported MC version 1.16.5ġ. Download my shaderpacks and place them in the newly opened window.ħ. Go to options -> video setings -> shaders and press on the "Shaders folders" button at the bottom of the screen.Ħ. Run the minecraft launcher and select the newly created optifine profile.ĥ. It will install a new optifine profile.ģ. Download and run the optifine jar file with Java. Note: Iris Sodium can also be installed as a fabric mod.Ģ. Select my shaderpack from the list ingame and enjoy your new visuals! Download my shaderpacks and place them in the newly opened window.Ĩ. Go to options -> video setings -> "Shader Packs" and press on the "Open Shader Pack folder" button.ħ. (Create a new profile if it didn't create one)Ħ. Run the minecraft launcher and select the newly created profile. In the installer, select "Iris and Sodium" pick your minecraft version and uncheck "install as fabric mod" then hit install.Ĥ. Download and run the Iris jar file with Java.ģ. Download and install Minecraft, setup your game profile of the version you want to run.Ģ. Minecraft Browse Iris Shaders Iris Shaders By coderbot Mods 16,777,954 Updated Description Files Images Source Relations Issues File Details Iris 1.4 for Minecraft 1.19.2 By IMS21 Release 2.49 MB 1.0M 1.19.2 Fabric 1 File Name iris-mc1.19.2-1.4.0.jar Supported Versions 1.19. Although new game versions may sometimes introduce issues, you're more bound by the version of Optifine you're using, which fortunately usually updates quite quickly after major Minecraft version changes.1. You don't often need to worry about version compatibility for the shaderpacks you're using. ![]() ![]() Select any of your added shader packs from the Shaders menu.They're both great pieces of art, but you. Shader packs just aren't interchangeable, just like how you cannot hand a copy of The Last Supper to someone who wants a copy of the Mona Lisa. zip file shader pack you've downloaded into this "shaderpacks" folder And while Canvas now has a few nice shaders like Lumi Lights, I still want to have the option of using existing shader packs that were designed for OptiFine. Alternatively, you can find this folder manually at C:\Users\\AppData\Roaming\.minecraft\shaderpacks.In your Minecraft menu, select Options > Video Settings > Shaders > Shaders Folder.Back in your launcher, select "Optifine" as the installation you'd like to play.jar file, which will automatically install Optifine. ![]()
![]() ![]() ![]() Duncan continues to conform to the statutory definition of a sexual psychopath." "His preoccupation with deviant sexual fantasies of one kind or another date back to the age of 12," one therapist wrote after evaluating Duncan in 1982. After his arrest for that crime, he told authorities that he had raped 13 boys by the time he was 16.Īnd authorities now believe that while free on parole in 1997, Duncan kidnapped, raped and murdered a 10-year-old boy in Southern California. In 1980, at the age of 17, he earned a 20-year prison sentence for raping and torturing a 14-year-old boy at gunpoint. Long before the carnage at the Groene home in Coeur d'Alene, Idaho, Duncan had unleashed his demons on the world. But if an unhappy childhood were all it took to create a sadistic pedophile, every town in America would live under perpetual Amber Alert. Those defects can be caused by traumatic childhood experiences, genetics or events that happen as a person's brain develops in the womb before birth.īut whatever their source, they might eventually be used as a neurological "mark of Cain," offering both a warning of what a person might be capable of and an opportunity to prevent them from realizing that potential.įreudians might find the seeds of Duncan's behavior in his youth - a lonely childhood, a domineering mother, his parents' tumultuous relationship.Īn unhappy upbringing certainly increases a boy's chances of growing up to be a violent sexual offender. Many, perhaps most, dangerous sexual predators appear to possess one or more brain abnormalities that predispose them to their extreme criminal behavior. But researchers are beginning to understand how another organ, the brain, can conjure the demons that haunt Duncan and other violent sexual predators. It is hard to conceive a heart black enough to commit such evil acts. Two children dragged to a remote part of Montana, where both were sexually molested and the 9-year-old boy was murdered. The toll? Three members of an Idaho family bludgeoned to death. Three weeks later the demons won, authorities say. If they win then a lot of people will be badly hurt." "It is a battle between me and my demons," Duncan wrote in his Web log on April 24. For months, anyone could follow the epic struggle in the mind of Joseph Edward Duncan III - live, on the Internet. ![]() ![]() “The game is one for the romantics,” Robins said this week “because of the journeys both clubs have been on.”įor Luton, it would be the culmination of a wild ride which saw the team drop out of the Football League - the three divisions below the Premier League - in 2009 following a 30-point deduction for financial misconduct.Īt Coventry, Robins rebuilt the playing squad, helped hire a chief executive, arranged to have improved training facilities and attempted to rediscover the bond between players and fans through various community programs. It’s the world’s most lucrative one-off soccer match - worth at least $210 million to the winner in future earnings - and a game neither team could have expected to be in when they were playing each other in England’s fourth tier five years ago. On Saturday, Coventry takes on Luton in the Championship playoff final at Wembley Stadium for a place in the Premier League. ![]() I had a decent time, and I wonder if Capcom was forced to choose between the 2 franchises instead of expanding on both.Mark Robins will always be remembered as the guy who likely saved Alex Ferguson from getting fired three years into his storied tenure as Manchester United manager.Īnother one is taking place at Coventry City, a club where chaos has ruled for more than two decades but whose turbulent and troubled journey back to the Premier League is almost complete. Promising, but since it lacks the lighthearted quips found in DMC, it has a pronounced sense of the edginess found in some anime or comic books. ![]() The story and aesthetic borrow from themes of heaven and hell, the 7 sins, the afterlife, and so on. You also pick up items during combat that offer upgrades, stats and recovery. The game has an EXP system, and earned EXP can be spent on upgrades for both you and any of your unlocked/equipped spirits. You can also summon a spirit/demon that helps you in battle. Combos are present, they feel pretty limited, though this may be because this game came out right after DMC2, so this entire formula was still being developed. I won't be able to play through the entire game, but from what I've seen so far is there's swords (no guns) but you can still juggle enemies, jump and attack, etc. The old /r/patientgamers Essential Games ListĪlso from Capcom, Chaos Legion may be right up your alley. Please use flair to display what games you’re currently playing, not a punch line, username, tag, URL, or signature. New, mobile-friendly spoilers can be posted using the following formatting: Want to play online in a dead gaming community? ![]() We expect you to know these rules before making a post. ![]() Please click here to see our current rules. We no longer maintain our posting rules in Old Reddit. Join our Discord Join our Steam Group Follow us on Twitter Posting Rules Whether it's price, waiting for bugs/issues to be patched, DLC to be released, don't meet the system requirements, or just haven't had the time to keep up with the latest releases. A gaming sub free from the hype and oversaturation of current releases, catering to gamers who wait at least 12 months after release to play a game. ![]() ![]() ![]() The Amazon Cloud Player is focusing that cloud power for Internet-connected personal stereos. You'd never had to remove old files just so you can add new ones.Ĭloud computing is making such seemingly infinite storage a reality for all kinds of computing uses. It's like having an iPod with an infinite amount of storage space. Now imagine that you could store all the music you have now, plus all the music you'll ever buy, as MP3 files, and that you'd never have to worry about whether you have enough space to store your whole collection. Unfortunately, the cards, like iPods, can still only store so much at one time. This eliminates the need to repeatedly upload and erase files you just switch out the card when you want different music. Some manufacturers have produced players that use removable media such as SD cards. ![]() While personal stereo capacities have increased, they still have finite storage space. In its first ten years, iPod models went from 5 GB to 160 GB in capacity, letting you store days worth of music on a single, small device. In 2001, Apple released just such a device: the iPod. With the invention of new digital file formats like MP3, the next logical step for personal stereos was storing and playing music as digital files the same way you would on a computer hard drive. Audio cassettes only held up to two hours of music, and CDs about an hour and a half. For several years, the brand name Walkman was as popular as the name iPod today, being as synonymous with personal stereos as Kleenex is to facial tissue.Īs technology progressed, so did the storage capacity of the media used in personal stereos. If you had a Walkman, you could take your favorite tunes with you anywhere in a small, lightweight package. As simple as it was, the device revolutionized the way people listened to music. The original Walkman was a handheld, battery-powered cassette player with stereo headphones. Post not showing up? Have a suggestion? Message the mods.On July 1, 1979, Sony Corporation began selling the world's first personal stereo device, the Walkman. All posts must be selftexts No hit and run spam!Īpp is on sale (include the price in the title)Īpp Recommendations Top Community Alternatives Google Play Store Top Paid Apps Top Free Apps Trending Apps Related Subreddits (Hover).All posts must be app related This means no rumors of upcoming phones.New sources may be suggested by the community at any time, as long as they have policies against piracy. You may directly link to APKs Apk linking may only be from approved sources, or directly from the developer Approved sources are Google Play, apkmirror, XDA-Labs, and F-Droid.Exceptions are made at mod team's discretion. Additionally, a developer may only post once per month. You must engage the community, hit and run posts are not allowed. Self promotion guidelines When self promoting a app, your self promotion must be a self post tagged with.Videos inside self posts/comments are fine. Videos aren't allowed as posts by their self. ![]() A article that is "Top 5 apps to try today!" will not be allowed. This means that a article saying "Google Hangouts v6 released, here's what's new" is fine. Articles directly about a specific app are allowed. Blog articles about apps will be allowed within moderation. Posting a link to any pirated app or asking for a pirated app, or helping users pirate apps, is an immediate seven day ban. ![]() : a strange, objectionable, or monstrous person or thing. The Shadow XMaxx Tree is a car that could be obtained either by completing the All Thru The Night achievement, which required racing 300 times in a session with a holiday car during the 2012 Xmaxx Event, or by completing the It’s Back!!! What is the definition of wampus?ĭialectal. How do you get the shadow XMaxx tree in Nitro type? ![]() The XMaxx Xxpress is a car that could be obtained by completing the Runnin’ a Train achievement, which required completing 125 races with a holiday car during the 2016 Xmaxx Event. The Typiano Pizza Car is a car that can be obtained by completing the Psycho Racer achievement, which requires clocking 24 hours (1,440 minutes) of total race time. Can hav’nt g0ld PLX?Ĭan hav nt g0ld plx? is a car that can be obtained by completing the Xmaz spiritz!!! 11one! achievement, which must be manually rewarded by an admin. If there are no active bureaucrats, use the “Requests for adminship” page to nominate users to become admins or bureaucrats. The Wampus cat is a cat-like creature in American folklore that varies widely in appearance, ranging from frightful to comical, depending on region. “Sleigh All Day” and “Up to Snow Good” round out our festive pun-derful title additions, one each for free and Nitro Gold members. And if all you’ve ever wanted from life is to be Wampus’ Little Helper, you can nab that title right away by hitting level 2 this season. ![]() How do you get the wampus Little Helper title in Nitro type?ģ Titles. If a racer successfully beats it in a race, the racer will earn an additional $50,000 nitro cash. The wampus is a bot that randomly shows up in races. With NT’s shortened races, it’s technically easier to get a high speed.The world’s average typing speed is 38-40 WPM.The highest WPM anyone has ever obtained without cheating is joshuu with a high speed of 249 WPM.… All bots, other than The Wampus, use the “Nitro Type Bot” title. This time depends on the speed range that the race is in, and can range from 0-5 seconds. A bot appears after an amount of time when no racers join a race. What does Botting mean in Nitro type?īots are “racers” who are controlled by AIs. Travis is the brother of Austin Butler (aka Corndog) who is the co-founder of Nitro Type and and a fellow admin. Travis is one of the admins on Nitro Type as well as the co-founder of Nitro Type and. An animated variant of this car, the Corsa Error 503, was made available for purchase from the Shop. How do you get the Corsa Error 503 in Nitro type?īefore its corresponding achievement was replaced by the Nitro Pass, this car could be obtained by completing the Rank 12 achievement. The Corsa Mystica is a car that could be obtained by reaching Rank 17 during Season 33, which required reaching Level 17 (320 races). How do you get the Corsa Mystica in Nitro type? The Calculatron is a car that could be obtained by reaching Rank 38 during Season 29, which required reaching completing 444 races. How do you get the Calculatron car in Nitro type? The Wampus uses the title “You’ll Never Beat Me!”(which is exclusive to The Wampus). If a racer successfully beats The Wampus in a race, they will receive an extra $50,000. The Wampus is a bot that randomly shows up in races. The Rocky Roo is a car that could be purchased from the Dealership during the 2018 PAC Event, which would complete the PAC Basic achievement. How do you get the Rocky Roo in Nitro type? 50,000 races need to be finished before players get their hands on this elusive car. Its rarity doesn’t stem from a special event or holiday prize. ![]() How do you get the wild 500 in Nitro type?īeing the rarest car in the game, The Wild 500 is only for the most dedicated Nitro Type players. Similar to most games, admins give bans after they believe that a user has broken Nitro Type’s rules. A ban from Nitro Type entails an indefinitely-lasting inability to access one’s own account due to admin intervention. ![]() ![]() ![]() ![]() It has additional features like editing and annotation.Feature: It primarily lets users take screenshots.Lightshot main features & specifications summary You can download the GoFullPage extension for the Chrome browser here. It has over fifty-six thousand reviews with an average five-star rating. GoFullPage has racked more than a whopping five million downloads, the most downloaded screenshot extension for Chrome. New updates roll out every few months on average with bug fixes, improved animations, and new features. The add-on is constantly being updated and improved. You can save the images in formats including PNG, JPG, and PDF. GoFullPage is a free Chrome extension that allows you to grab a screenshot of the complete page without having to scroll and repeatedly take screenshots. It collects information like user identity, location, and user activity.GoFullPage - Full Page Screen Capture pros & cons Feature: It takes a screenshot of the whole page.GoFullPage - Full Page Screen Capture main features & specifications summary You can download the Awesome Screenshots & Screen Recorder extension for the Chrome browser here. Though the selected are screen capture can be buggy at times, it’s a helpful feature. To complement the screenshots, you can select the format in which you want the picture PNG, JPG, or download it as a PDF.Īwesome Screenshots & Screen Recorder has over two million downloads with an impressive average of five-star rating from users. You can even record the browser if you want. Selecting an area to take a screenshot of is a powerful tool. You can take the full browser shot or even a selected portion of the page if you want. You can take a screenshot of the browser with it. ![]() There are a few bugs with some featuresĪwesome Screenshots & Screen Recorder is a free extension that works on Google Chrome and Firefox.It can save images in different formats.It has additional features that complement the screenshot function.Feature: It can be used for screen recordingĪwesome Screenshot & Screen Recorder pros & cons.Browser compatibility: Chrome and Firefox.Awesome Screenshot & Screen RecorderĪwesome Screenshot & Screen Recorder main features & specifications summary They will help you figure out which one best suits your needs. Now that we’ve listed them, let’s get into the details of the six listed screenshot extensions for Chrome. List of the Top 6 Chrome Extensions for Screenshots Screenshot Tool - capture & editor: Lets users take three types of screenshots along with image editing options.Blipshot: one-click full page screenshots: Simple full page screenshot add-on.Screenpresso: Screenshot extension with a built-in image editor.Lightshot (screenshot tool): Captures screenshots with an editing and annotation option.GoFullPage - Full Page Screen Capture: Enables users to capture a whole website page in a single go.Awesome Screenshot & Screen Recorder: Lets users take screenshots and record page.Here’s the list of screenshot add-ons that can help you find what you’re looking for We were able to filter the list to six of the best screenshot extensions for Chrome. Here’s a list that rates six add-ons on safety, ease of use, features, and how they work with the Chrome browser, along with their pros and cons. There are numerous screenshot extensions in the Chrome Web Store, some safer and better than others. Extensions Recommended for Capturing Screenshots in Chrome It’s important to install safe, working extensions. They sometimes don’t work other times, they slow down the browser and can be a security risk as they can infect your browser with malware and viruses. While the extensions can be helpful, many of them come with security risks. ![]() ![]() ![]() RCTs are designed to test efficacy or effectiveness of an intervention compared to a control condition, while SMARTs allow identifying treatment strategies that would otherwise take multiple RCTs to evaluate. SMART designs are a generalization of conventional randomized controlled trials (RCT) that allow participants to be randomized more than once, depending on intermediate outcomes. These tailored AIs are also called deeply embedded AIs. ![]() Investigators can build more complex AIs (more deeply tailored AIs) using extra information collected on potential moderators (e.g., baseline characteristics of the individual and/or context, adherence to and/or side effects from prior treatment stages). Each stage in a SMART design corresponds to one of the critical decisions involved in the AI. Each patient is randomly assigned to initial treatment and subsequent treatments are based on the intermediate outcome and patient’s characteristics. ĪIs are said to be embedded in a SMART study. The sequential multiple assignment randomization trial (SMART) is design that involves multiple stages of randomization, and is used to develop and refine effective AIs, also known as dynamic treatment regimens (DTR), adaptive treatment strategies (ATS), multistage treatment strategies (MTS), proportionate interventions, or treatment policies. 4) decision rule(s), linking the tailoring variable(s) to the intervention components, at each critical decision point. 3) tailoring variable(s), an early indicator of the overall outcome (success or failure of the intervention). 2) intervention component(s), a set of intervention/treatment options at each critical decision point. Often there will be a huge number of potential AIs that could be used, and it is difficult to collect robust information on which perform best.Īn AI consists of four key elements: 1) critical decision point(s), comprising: the intervention to begin with when and how to measure signs of response/nonresponse how to maintain the success of the initial intervention and what interventions may be used for non-responders. This strategy would account for the patient’s treatment history and response to those treatments. An adaptive intervention (AI), sometimes referred to as dynamic treatment regimens (DTRs), is a treatment strategy that formalizes the personalization of treatment through established decision rules that recommend when and how the treatment should change. ![]() |